In order to perform with peak accuracy, uniformity, and speed, the thermal optimization of the product needed to be designed with a heat sink configuration that maintained less than +/-0.5°C variation in temperatures from sample to sample.
Aavid also needed to determine the feasibility of removing edge heaters from the sample block by recommending an appropriate insulation scheme and thermal interface materials.
DNA Cycler/Thermal Cycler Case Study
Aavid engineers evaluated several fan and heat sink combinations by creating airflow-thermal simulation models to choose a particular fan, number of fans, location of fans, heat sink geometry, etc. These simulations helped in the selection of an optimal combination of fan and heat sink. The team then created a prototype of the unit to capture all heat and airflow related details. The prototype was tested for temperature variation and the data was used to enhance the accuracy and reliability of simulation predictions.
To further optimize the overall product design, Aavid engineers evaluated the feasibility of removing heaters used to minimize the sample to sample temperature variation. It was shown using simulations that placing polyurethane foam at key locations can maintain the sample to sample temperature variation without the side heaters.
Bio-Rad utilized the recommended Aavid solution and implemented it into their Thermal Cycler design, which is still being produced today.
This Bio-Rad Thermal Cycler has now been in use for several years with excellent results. Over the years, the final products have maintained their accuracy and reliability and Bio-Rad is known for their robust, high performing PCR amplification equipment.
Have questions? We're ready to help!